Expressions (phrases, clauses, etc.), Ichidan verb
to feel keenly; to strike to the core; to touch to the quick; to hit home to one
彼の忠告が骨身に染みた。His advice cut me to the quick. to pierce deep inside (e.g. of cold)
Also written 骨身に沁みる【ほねみにしみる】、骨身に染みる【ほねみにしみる】