Noun
being done for; giving up; being in a hopeless situation; not knowing what to do; being brought to one's knees; throwing up (one's) hands
火災で全てのコンピューターディスクが駄目になってしまった時、会社はもうお手上げの状況だった。The company faced a major interruption in business when a fire destroyed their archive of computer hard drives and optical discs.
Also written お手あげ【おてあげ】