1. Expressions (phrases, clauses, etc.), Kuru verb - special class

   to get angry; to get mad; to lose one's temper; to fly into a rage; to blow one's top

   これは頭にくる。

2. to go straight to one's head (of alcohol); to feel the effects (of an illness); to lose one's wits

Also written 頭に来る【あたまにくる】atamanikuru