Noun
beginning; start; first step
とても魅力的な人に初めて会って、話の糸口を見つけるのは、たいていかなり難しいものだ。People usually find it very difficult to break the ice when they meet someone extremely attractive for the first time. clue; lead; hint
thread end
Also written 緒【いとぐち】、絲口【いとぐち】