Expressions (phrases, clauses, etc.), Godan verb with 'su' ending
to be disgusted with; to run out of patience; to fall out of love
彼女は、甲斐性のない夫に愛想を尽かして離婚しました。Disgusted with her good-for-nothing husband, she divorced him.
Also written 愛想をつかす【あいそをつかす】